AbbVie Stemcentrx Develops New Approach to Treating Cancer with SGI Supercomputer

The influx of unstructured data is having an increasingly strong impact on cancer and medical research organizations, and many currently lack the technology and power to derive scientific insights in order to speed up the discovery of diagnoses and treatments. Organizations are beginning to turn to high performance computing to facilitate their research with powerful analyses and management of data.

SGI Helps Scientists Target Cancer Stem Cells and Develop Treatments that Attack Tumors at the Roots
AbbVie Stemcentrx, one of many research companies turning to HPC to overcome obstacles with its large data workloads, has selected SGI® UV™ 300 to elevate its investigation of cancer. As a leader in genomics research with a strong mission to pioneer new therapies for curing diseases, AbbVie Stemcentrx leverages their SGI UV 300 to assist with bioinformatics initiatives that require significant levels of compute power, such as analyzing large and complex datasets for cancer therapy and genetics sequencing research.

“We are excited to enable AbbVie Stemcentrx in their groundbreaking research in personalized cancer treatments,” said Gabriel Broner, vice president and general manager, high-performance computing at SGI. “Having interacted with passionate people whose quest is to improve treatments and cure diseases with fewer side effects, we at SGI are incredibly motivated by the better future that lies ahead, and our teams come to work every day motivated to build the supercomputers that enable that better future.”

DNA Sequencing Costs Declining Rapidly
The advancement in stem cell research with the use of supercomputers means that sequencing DNA, research that once cost up to $3 billion and 10 years, now takes 26 hours for $20,000. Return on investment was a major factor in AbbVie Stemcentrx’s decision to partner with SGI. The time-savings made possible by the SGI UV 300 system will cover the investment costs within two months. Considering it can cost up to $1 billion to take a drug to market, accelerating the analysis and data processes during the three phases of the clinical FDA-monitored trials can leave a major impact on a company’s potential for success.

“Our new SGI UV 300 capabilities will help us achieve major milestones sooner than predicted,” said Albert Park, senior director, Bioinformatics, AbbVie Stemcentrx. “The new SGI system is able to process larger quantities of data faster than ever and provides us with ease of management. We see significant advantages of having a single OS control our systems, including ease of use, lower power consumption and increased compute power. There’s no price tag for technology that can help discover a drug that will save millions of lives.”

Faster than Ever Before, Stemcentrx Can Now Annotate and Re-annotate Genetic Sequences in Three Days
To best recognize, target and eliminate the cancer stem cells that are responsible for tumors, AbbVie Stemcentrx analyzes multiple datasets at once. By increasing the amount of data the bioinformatics team is processing, they are also able to increase the amount of useful information that is generated. With the high-performance computing technology from SGI, AbbVie Stemcentrx is able to annotate and re-annotate genetic sequences in three days — down from three weeks.

Technical Information
• The new AbbVie Stemcentrx platform comprises of SGI UV 300 systems totaling 6TB of RAM, 16 sockets and 18 core CPUs.
• Featuring Intel® Xeon® E7-8800 v4 and Intel® Xeon® E7-4800 v4 processors and a NUMAlink topology with ultra-low latency, these servers provide a greater memory to processor ratio.
• Paired with 12TB NVME flash technology, the solution helps increase processing speeds of heavy workloads.

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